Yalcin, B | Sancar, M | Izzettin, FV

Conference Object | 2008 | PHARMACY WORLD & SCIENCE30 ( 5 ) , pp.705 - 706

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Yavuz, DG | Bilen, H | Sancak, S | Galip, T | Hekimsoy, Z | Sahin, I | Guvener, N

Conference Object | 2014 | DIABETOLOGIA57 , pp.705 - 706

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Goktas, C | Coskun, A | Bicik, Z | Horuz, R | Unsal, I | Serteser, M | Sarica, K

Article | 2012 | UROLOGICAL RESEARCH40 ( 5 ) , pp.569 - 573

Extracorporeal shockwave lithotripsy (ESWL) has dramatically changed the treatment of urinary lithiasis and has been the first treatment option for the majority of patients for more than two decades. Despite its significant benefits, it induces acute renal injury that extends from the papilla to the outer cortex. We evaluated the severity of the inflammatory response to ESWL by measuring the urinary excretion of the cytokines TNF-alpha, IL-1 alpha, and IL-6. The study included 21 selected patients and 14 control subjects. All patients underwent the same ESWL procedure (2,500 shockwaves at 100 shockwaves/min and 0.039 J from the lith . . .otripter). Urine TNF-alpha, IL-1 alpha, and IL-6 levels were measured using standard ELISA kits. In the study population (patients and controls), we did not detect TNF-alpha in the urine samples. The levels of both IL-1 alpha (2.5 pg/ml) and IL-6 (3.8 pg/ml) measured before ESWL were not significantly different from the control group (2.5 and 5.2 pg/ml, respectively; p > 0.05). Twenty-four hours after ESWL, in contrast to IL-1 alpha (4 pg/ml), urine IL-6 (19.7 pg/ml) increased significantly (p < 0.05). Fourteen days after ESWL, IL-1 alpha increased to 5 pg/ml, while IL-6 (7 pg/ml) decreased to the control level. Urine cytokine levels may be used to evaluate the inflammatory response to ESWL. After ESWL, IL-6 levels increased in the early phase, while IL-1 alpha levels increased later. These two markers may be used to measure the severity of inflammation. In contrast to IL-1 alpha and IL-6, urine TNF-alpha excretion was not increased by ESWL. We believe that the inflammatory response to ESWL can be detected by the urinary excretion of IL-1 alpha for up to 14 days Daha fazlası Daha az

Dogan, EAI | Eroglu, A | Turkeri, L | Ekici, S

Conference Object | 2009 | VIRCHOWS ARCHIV455 , pp.151 - 151

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Sahin, ZS | Ozkan, I | Koksal, M | Isik, S

Article | 2012 | JOURNAL OF STRUCTURAL CHEMISTRY53 ( 5 ) , pp.938 - 942

5-(3,4-Dichlorophenyl)-3-{[4-(2-pyridyl)piperazine-1-yl)]methyl}-1,3,4-oxadiazole-2(3H)-one C18H17Cl2N5O2 (3) is synthesized and characterized by IR, H-1 NMR, C-13 NMR, elemental analyses, single-crystal X-ray diffraction, and the molecular structure is also optimized at the B3LYP/6-31G(d,p) level using density functional theory (DFT). All data obtained from the spectral studies support the structural properties of 3. The molecules are linked principally by C-HaEuro broken vertical bar O hydrogen bonds involving carbonyl atoms and carboxylate O atoms, forming R (2) (2) (16) and R (4) (2) (20) rings that link to give a one-dimensiona . . .l network of molecules. An extensive two-dimensional network of C-HaEuro broken vertical bar O hydrogen bonds and pi aEuro broken vertical bar pi interactions are responsible for crystal stabilization Daha fazlası Daha az

Ozcan, P | Parasar, P | Ficicioglu, C

Correction | 2017 | CURRENT OBSTETRICS AND GYNECOLOGY REPORTS6 ( 1 ) , pp.33 - 33

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Ozcan, P | Parasar, P | Ficicioglu, C

Article | 2017 | CURRENT OBSTETRICS AND GYNECOLOGY REPORTS6 ( 1 ) , pp.26 - 32

Primary ovarian insufficiency (POI), a clinical syndrome, is defined by the exhaustion of the functional potential of ovaries prior to 40 years. The consequences of POI are potentially serious for long-term fertility, reproductive health, and general health because of early menopause. This article provides an updated review of different etiologic factors and pathogenic mechanisms that lie behind POI as well as current and novel strategies for the management of this challenging disease aimed at the primary prevention of the adverse effects of estrogen deficiency and infertility related to the early loss of ovarian function. POI is co . . .nsidered as a multifactorial and heterogeneous condition with a wide spectrum of causes, such as cytogenetic, autoimmune, infectious, metabolic, or iatrogenic causes. Most women affected with isolated POI still appear sporadically, and the exact underlying pathology remains unknown. For early prediction of the risk of POI and prevention of the detrimental consequences of POI in terms of fecundity and general health, the determination of characteristics and the risk assessment of the POI population may be more important than the prediction of the prevalence of POI in the general population. POI has widespread consequences for general health and fertility. Challenges remain in the modalities of assessment and management of this complex condition. This review primarily focuses on the key questions and recommendations for clinical practice regarding the assessment and management of women diagnosed with POI. Therefore, this article provides an updated review of novel findings regarding the diagnosis and management of this challenging disease Daha fazlası Daha az

Ceyhan, EM | Clark, PM

Conference Object | 2009 | PHARMACY WORLD & SCIENCE31 ( 1 ) , pp.76 - 76

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Demir, Z | Sevli, S | Bayrak, O | Ozen, M

Conference Object | 2009 | CHROMOSOME RESEARCH17 , pp.113 - 113

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Mercarloglut, G | Satran, N | Pamukcu, B | Fici, F

Conference Object | 2007 | CARDIOVASCULAR DRUGS AND THERAPY21 , pp.113 - 113

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Atalay, B | Ture, U

Article | 2014 | NEUROSURGICAL REVIEW37 ( 2 ) , pp.339 - 345

Fixed atlantoaxial dislocations are difficult to treat and there is no consensus in the treatment protocol. Unilateral enlargement of the atlas-axis facet complex in fixed atlantoaxial dislocations is a very rare condition. These pathologies are usually quite unstable and surgical treatment is necessary in unreductable cases. A 52-year-old woman with a diagnosis of irreducible-fixed rotatory atlantoaxial dislocation presented with acute onset of dizziness, loss of balance, and tetraparesis. She was under 8 years of conservative follow-up. Review of radiology revealed unilateral C2 superior facet hypertrophy compressing the medulla a . . .nd obstructing the vertebral artery. To treat this condition, we have used a posterior midline approach and removed the lateral portions of the posterior rim of the foramen magnum and the assimilated posterior arch of C1. The V3 segments of the vertebral arteries were exposed bilaterally. The atlantoaxial joint complex on the left was hypertrophied compressing V3. We have removed hypertrophied lateral mass of the atlas and the hypertrophic superior articular facet of C2 for decompression. Patency of both vertebral arteries were checked intraoperatively by Doppler and indocyanine green angiography. We have fixated craniocervical junction on the same session. Patient was neurologically intact and she had confirmed fusion on the surgical site after three years of follow-up. This is a rare case of unilateral hypertrophy of the C2 superior articular facet in a fixed atlantoaxial rotatory dislocation. Progressive compression of medulla and the left vertebral artery leaded to clinical worsening of neurology in this case after 8 years of follow-up. Surgical treatment was necessary for neurological decompression and to establish stability Daha fazlası Daha az

Akovali, B | Akgun, EK | Sahin, O | Yeyin, N | Abuqbeitah, M | Tanyildizi, H | Kabasakal, L

Conference Object | 2018 | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING45 , pp.339 - 345

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