Okan, BS | Marset, A | Zanjani, JSM | Sut, PA | Sen, O | Culha, M | Menceloglu, Y

Article | 2016 | JOURNAL OF APPLIED POLYMER SCIENCE133 ( 22 )

Three-dimensional fluorinated pentablock poly(L-lactide-co-epsilon-caprolactone)-based scaffolds were successfully produced by the incorporation of thermally exfoliated graphene oxide (TEGO) as an antimicrobial agent with an electrospinning technique. In a ring-opening polymerization, the fluorinated groups in the middle of polymer backbone were attached with a perfluorinated reactive stabilizer having oxygen-carrying ability. The fiber diameter and its morphologies were optimized through changes in TEGO amount, voltage, polymer concentration, and solvent type to obtain an ideal scaffold structure. Instead of the widely used graphen . . .e oxide synthesized by Hummer's method, TEGO sheets having a low amount of oxygen produced by thermal expansion were integrated into the fiber structure to investigate the effect of the oxygen functional groups of TEGO sheets on the degradation and antimicrobial activity of the scaffolds. There was no antimicrobial activity in TEGO-reinforced scaffolds in the in vitro tests in contrast to the literature. This study confirmed that a low number of oxygen functional groups on the surface of TEGO restricted the antimicrobial activity of the fabricated composite scaffolds. (C) 2016 Wiley Periodicals, Inc Daha fazlası Daha az

Albayrak, C | Kavakli, K | Ar, C | Albayrak, D | Kilinc, Y | Baslar, Z | Caglayan, H

Conference Object | 2019 | HAEMOPHILIA25 , pp.63 - 64

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Kibici, D | Kahveci, D

Article | 2019 | JOURNAL OF FOOD SCIENCE84 ( 6 ) , pp.1273 - 1280

The effect of emulsifiers, emulsion stabilizer (maltodextrin, MD), and beta-cyclodextrin (BCD) on physical and oxidative properties of oil-in-water (O/W) emulsions (5%, 20%, 40% of oil, w/w) was investigated. Four different emulsifiers were selected based on their structure: two types of protein-based emulsifiers (sodium caseinate, SC; and whey protein isolate, WPI), and two types low molecular weight emulsifiers (LMEWs: lecithin, LEC; and Citrem, CITREM). Physical and oxidative stability of emulsions prepared with these emulsifiers together with MD were compared based on their creaming index (CI), viscosity, droplet size, zeta pote . . .ntial, peroxide and p-anisidine values. LMWE-stabilized emulsions (with LEC or CITREM) had better creaming stability with lower droplet sizes whereas protein-stabilized emulsions (with SC or WPI) had higher viscosities. Droplet size was the lowest when CITREM was used, which increased with increasing oil concentration for all emulsifiers. Formulation with the lowest CI value and droplet size was considered to be more prone to oxidation; therefore, a 1:1 (w/w) combination of CITREM with BCD was used to stabilize the emulsions to improve the oxidative as well as physical stability. Added BCD significantly increased the storage stability of emulsions by reducing CI and droplet size values with a simultaneous increase in the viscosity, both at room temperature and at storage conditions (at 4 and 55 C-o). However, the oxidative as well as physical stability of BCD added emulsions were not improved, neither toward heat- nor light-induced lipid oxidation. Practical Application This work investigated the effects of emulsifiers and dextrins on the stability of oil-in-water (O/W) emulsions. Both maltodextrin (MD) and beta-cyclodextrin (BCD) addition resulted in enhanced physical stability, the latter being more effective. The findings can be applied to formulate emulsions with improved shelf life within the limits of allowed daily intake (ADI) level of BCD (5 mg/kg bw per day) Daha fazlası Daha az

Chopra, SS | Leshchiner, I | Duzkale, H | McLaughlin, H | Giovanni, M | Zhang, CS | Cassa, CA

Article | 2015 | MOLECULAR GENETICS & GENOMIC MEDICINE3 ( 5 ) , pp.413 - 423

Glycosaminoglycans (GAGs) such as chondroitin are ubiquitous disaccharide carbohydrate chains that contribute to the formation and function of proteoglycans at the cell membrane and in the extracellular matrix. Although GAG-modifying enzymes are required for diverse cellular functions, the role of these proteins in human development and disease is less well understood. Here, we describe two sisters out of seven siblings affected by congenital limb malformation and malignant lymphoproliferative disease. Using Whole-Genome Sequencing (WGS), we identified in the proband deletion of a 55 kb region within chromosome 12q23 that encompasse . . .s part of CHST11 (encoding chondroitin4-sulfotransferase 1) and an embedded microRNA (MIR3922). The deletion was homozygous in the proband but not in each of three unaffected siblings. Genotyping data from the 1000 Genomes Project suggest that deletions inclusive of both CHST11 and MIR3922 are rare events. Given that CHST11 deficiency causes severe chondrodysplasia in mice that is similar to human limb malformation, these results underscore the importance of chondroitin modification in normal skeletal development. Our findings also potentially reveal an unexpected role for CHST11 and/or MIR3922 as tumor suppressors whose disruption may contribute to malignant lymphoproliferative disease Daha fazlası Daha az

Kori, M | Werkstetter, K | Sustmann, A | Lopez, A | Cabral, J | Iwanczak, B | Koletzko, S

Conference Object | 2017 | HELICOBACTER22 , pp.413 - 423

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Ugras, M | Berber, M | Akoluk, A

Conference Object | 2017 | HELICOBACTER22 , pp.413 - 423

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Dag, I | Kocman, E | Sengel, T | Soztutar, E | Canbek, M

Conference Object | 2017 | GLIA65 , pp.413 - 423

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Kebudi, R | Tugcu, D | Akici, F | Celkan, T | Vural, S | Tokuc, G | Darendeliler, E

Conference Object | 2017 | PEDIATRIC BLOOD & CANCER64 , pp.413 - 423

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Qureshi, MZ | Attar, R | Romero, MA | Sabitaliyevich, UY | Nurmurzayevich, SB | Ozturk, O | Farooqi, AA

Article | 2019 | JOURNAL OF CELLULAR BIOCHEMISTRY120 ( 8 ) , pp.12091 - 12100

Entry of beta-elemene into various phases of clinical trials advocates its significance as a premium candidate likely to gain access to mainstream medicine. Based on the insights gleaned from decades of research, it seems increasingly transparent that beta-elemene has shown significant ability to modulate multiple cell signaling pathways in different cancers. We partition this multicomponent review into how beta-elemene strategically modulates various signal transduction cascades. We have individually summarized regulation of tumor necrosis factor related apoptosis-inducing ligand, signal transducers and activators of transcription, . . . transforming growth factor/SMAD, NOTCH, and mammalian target of rapamycin pathways by beta-elemene. Last, we will discuss the results of clinical trials of beta-elemene and how effectively we can use these findings to stratify patients who can benefit most from beta-elemene Daha fazlası Daha az

Agus, S | Atasayan, O | Sandal, S | Mete, F | Eyuboglu, S | Yılmaz, B

Conference Object | 2017 | ACTA PHYSIOLOGICA221 , pp.121 - 121

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Ugras, M | Cam, S | Coban, J | Pehlivanoglu, E

Conference Object | 2018 | HELICOBACTER23 , pp.121 - 121

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Gumral, D | Fogolari, F | Corazza, A | Viglino, P | Giorgetti, S | Stoppini, M | Esposito, G

Article | 2013 | MAGNETIC RESONANCE IN CHEMISTRY51 ( 12 ) , pp.795 - 807

The amyloid pathology associated with long-term haemodialysis is due to the deposition of (2)-microglobulin, the non-polymorphic light chain of class I major histocompatibility complex, that accumulates at bone joints into amyloid fibrils. Several lines of evidence show the relevance of the tryptophan residue at position 60 for the fibrillogenic transition of the protein. A comparative N-15 NMR relaxation analysis is presented for wild-type human (2)-microglobulin and W60G (2)-microglobulin, i.e. the mutant with a glycyne replacing the natural tryptophan residue at position 60. The experimental data, collected at 11.4T and 310K, wer . . .e analyzed by means of the reduced spectral density approach. Molecular dynamics (MD) simulations and corresponding thermodynamic integration, together with hydrodynamic calculations were performed to support data interpretation. The analysis results for the mutant protein are consistent with a reduced aggregation with respect to the wild-type counterpart, as a consequence of an increased conformational rigidity probed by either NMR relaxation and MD simulations. Although dynamics in solution is other than fibrillar competence, the assessed properties of the mutant protein can be related with its reduced ability of forming fibrils when seeded in 20% trifluoroethanol. Copyright (c) 2013 John Wiley & Sons, Ltd Daha fazlası Daha az