F. Halicioglu

Article | 2007 | Energy Economics29 ( 2 ) , pp.199 - 210

This article provides fresh empirical evidences for the income and price elasticies of the residential energy demand both in the short-run and long-run for Turkey over the period 1968-2005, using the bounds testing procedure to cointegration. The computed elasticities of income and price are consistent with the previous studies and, as expected, the long-run elasticities are greater than the short-run elasticities. An augmented form of Granger causality analysis is implemented among residential electricity, income, price and urbanization. In the long-run, causality runs interactively through the error-correction term from income, pr . . .ice and urbanization to residential energy but the short-run causality tests are inconclusive The parameter stability of the short-run as well as long-run coefficients in the residential energy demand function are tested. The results of these tests display a stable pattern. © 2006 Elsevier B.V. All rights reserved Daha fazlası Daha az

A. Palotás | H.J. Reis | G. Bogáts | B. Babik | M. Racsmány | L. Engvau | J. Kálmán

Article | 2010 | Journal of Alzheimer's Disease21 ( 4 ) , pp.1153 - 1164

Several biomarkers are used in confirming the diagnosis of cognitive disorders. This study evaluates whether the level of these markers after heart surgery correlates with the development of cognitive dysfunction, which is a frequent complication of cardiac interventions. Concentrations of amyloid-ß peptide, tau, and S100ß in the cerebro-spinal fluid were assessed, as well as cognitive functions were evaluated before and after coronary artery bypass grafting, utilizing immuno-assays and psychometric tests, respectively. A drastic rise in the level of S100ß was observed one week after the surgery, a mark of a severe generalized cereb . . .ral injury. The level of amyloid-ß peptide significantly decreased, whereas the concentration of tau markedly increased six months postoperatively. Gradual cognitive decline was also present. These findings clearly demonstrate post-surgical cognitive impairment associated with changes in biomarkers similar to that seen in Alzheimer's disease, suggesting a unifying pathognomic factor between the two disorders. A holistic approach to coronary heart disease and Alzheimer's-type dementia is proposed. © 2010 IOS Press and the authors. All rights reserved Daha fazlası Daha az

Ataman, AD | Vatanoglu-Lutz, EE

Article | 2012 | JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH29 ( 4 ) , pp.895 - 899

During the times of World War I, Germany was an important pioneer in many areas of science and medicine. Alois Alzheimer, who lived during this period, was one of the founders of the field of neuropathology. He described a form of dementia as a brain destroying disease more than 100 years ago. This paper provides an overview on the discovery of the Alzheimer disease and the physician behind this discovery, Alois Alzheimer, through philately.

Cam, E. | Yulug, B. | Cengiz, N. | Poelkin, E. | Isyk, D. | Bakar, M. | Kilic, E.

Letter | 2008 | Journal of Neuropsychiatry and Clinical Neurosciences20 ( 4 ) , pp.498 - 500

[No abstract available]

Say, E.C. | Koray, F. | Tarim, B. | Soyman, M. | Gülmez, T.

Article | 2004 | Quintessence International35 ( 1 ) , pp.56 - 60

Objective: To evaluate the effect of two cavity disinfectants, a 2% chlorhexidine and a 1% benzalkonium chloride solution, on the shear and tensile bond strengths of dentin bonding systems to dentin. Method and materials: Superficial dentin was exposed from 84 freshly extracted human third molars. The teeth were randomly assigned to two main groups according to the bonding agent used, either One Step or Optibond Solo. Each dentin bonding system had six test groups (three for shear, three for tensile testing), and each test group had a control and two cavity disinfectant groups. In the control groups, dentin bonding systems were appl . . .ied after etching the dentin, whereas in the cavity disinfectant groups, dentin was conditioned and treated for 20 seconds with the disinfectants before applying the dentin bonding systems. A hybrid resin composite then was applied to all treated samples. After storage in distilled water at 37°C for 24 hours, shear and tensile tests were performed. Data were analyzed using Kruskall-Wallis and Mann-Whitney U tests. Results: The mean shear and tensile bond strengths of One Step and Optibond Solo were not significantly different from each other, and the cavity disinfectants also had no significant effects on shear and tensile bond strength values versus the controls. Conclusion: The results indicate that the use of 2% chlorhexidine and 1% benzalkonium chloride solutions as cavity disinfectants after etching the dentin did not affect the shear and tensile bond strengths of One Step and Optibond Solo Daha fazlası Daha az

Tunç, M. | Çamdali, Ü. | Parmaksizoglu, C.

Article | 2006 | Energy Policy34 ( 1 ) , pp.50 - 59

Energy issues are directly related to the development of a country and the living standards of its people. Turkey is currently in a rapid industrialization process with a young and dynamic population of over 65 million. Due to relatively high growth rate of the population, increasing consumer oriented attitudes and as a result of rising levels of affluence, the primary energy demand is rising rapidly at an annual rate of 6.7 percent. In this study Turkey's energy resources, installed electric power capacity, electric energy production and consumption rates are investigated and compared with that of France, Germany and Switzerland. T . . .urkey's electric energy consumption rates are predicted with regression analysis for the years of 2010 and 2020 and finally linear mathematical optimization model is developed to predict the distribution of future electrical power supply investments in Turkey. © 2004 Elsevier Ltd. All rights reserved Daha fazlası Daha az

Aksoy, Ü. | Çelebi, A.O.

Conference Object | 2010 | Operator Theory: Advances and Applications205 , pp.129 - 141

Polyharmonic hybrid Green functions, obtained by convoluting polyharmonic Green and Almansi Green functions, are taken as kernels to define a hierarchy of integral operators. They are used to investigate the solvability of some types of Dirichlet problems for linear complex partial differential equations with leading term as the polyharmonic operator. © 2009 Birkhäuser Verlag Basel/Switzerland.

Alakent, B. | Baskan, S. | Doruker, P.

Article | 2011 | Journal of Computational Chemistry32 ( 3 ) , pp.483 - 496

Effects of ligand binding on protein dynamics are studied via molecular dynamics (MD) simulations on two different enzymes, dihydrofolate reductase (DHFR) and triosephosphate isomerase (TIM), in their unliganded (free) and liganded states. Domain motions in MD trajectories are analyzed by collectivities and rotation angles along the principal components (PCs). DHFR in the free state has well-defined domain rotations, whereas rotations are slightly damped in the binary complex with nicotinamide adenine dinucleotide phosphate (NADPH), and remarkably distorted in the presence of NADP+, showing that NADP+ is solely responsible for the l . . .oss of correlation of the domains in DHFR. Although mean square fluctuations of MD simulations in the same PC subspaces are similar for different ligation states, linear stochastic time series models show that backbone flexibility along the first five PCs is decreased upon NADPH and NADP+ binding in subpicosecond scale. This shows that mobility of the protein along the PCs is closely related with intraminimum dynamics, and alterations in ligation states may change the intraminimum dynamics significantly. Low vibrational frequencies of the alpha-carbon atoms of DHFR are determined from the time series models of a larger number of low indexed PCs, and it is found that number of modes in the lowest frequencies is reduced upon ligand binding. A similar result is obtained for TIM in the unliganded and dihydroxyacetone phosphate bound states. We suggest that stochastic time series modeling is a promising method to be used in determining subtle perturbations in protein dynamics. © 2010 Wiley Periodicals, Inc Daha fazlası Daha az

Kirmizibekmez, H. | Kúsz, N. | Karaca, N. | Demirci, F. | Hohmann, J.

Article | 2017 | Natural Product Communications12 ( 1 ) , pp.59 - 61

A new phenylethanoid glycoside, named digiviridifloroside (1), was isolated from the leaves of Digitalis viridiflora Lindley along with a known phenylethanoid glycoside, calceolarioside A (2), two flavonoid glycosides, scutellarein 7-O-ß-D-glucopyranoside (3) and hispidulin 7-O-ß-D-glucopyranoside (4), two cleroindicins, cleroindicins B (5) and F (6), a nucleoside, adenosine (7), as well as a mixture of ß-glucopyranosyl-(1›6)-4-O-caffeoyl-/ß-glucopyranose and 3,4-dihydroxyphenylethanol. The structure of the new compound was established as 3,4-dihydroxy-ß-phenylethoxy-6-O-(E)-feruloyl-ß-glucopyranosyl-(1›6)-4-O-(E)-caffeoyl-ß-glucopy . . .ranoside (1) based on extensive 1D-and 2D-NMR spectroscopy, as well as HR-ESI-MS. Digiviridifloroside represents a rare type of phenylethanoid glycoside which bears two aromatic acyl units in its structure. In addition to phytochemical studies, the isolates were evaluated for their in vitro antimicrobial activities against three pathogenic bacteria and three yeast strains using a microdilution method. Among the tested compounds, 5 exhibited moderate antibacterial activity against Bacillus cereus NRRLB 3711 with a MIC value of 25 µg/mL, whereas compounds 5 and 6 showed relatively high anticandidal activity against Candida strains with MIC values down to 12.5 µg/mL, in comparison to the standard antimicrobial compounds Daha fazlası Daha az

Ozcan, E | Aydin, K | Baser, GM | Guclu-Ustundag, O | Korachi, M | Ekinci, FY

Conference Object | 2012 | NEW BIOTECHNOLOGY29 , pp.59 - 61

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Altunbek, M. | Çetin, D. | Suludere, Z. | Çulha, Mustafa

Article | 2019 | Talanta191 , pp.390 - 399

Three-dimensional (3D) spheroid cultures are more realistic tissue mimicking structures for drug discovery studies. However, analysis of 3D spheroid cultures is a challenge task because available techniques are destructive, which results with the loss of biochemical information confined in a spatial arrangement inside of spheroids. In this study, a surface-enhanced Raman scattering (SERS) based non-destructive approach is reported to study 3D cultures. Since the technique uses gold nanoparticles (AuNPs) as SERS substrates, the cells treated with AuNPs are used for the preparation of spheroids. Since SERS spectra originate from molec . . .ular species near AuNPs and their aggregates in endolysosomes, the obtained spectral information can provide significant level of information about biomolecular processes taking place in endolysosomes and dependently in cells. The performance of the approach is evaluated by monitoring the spectral changes upon external stimuli with Doxorubicin (Dox) and Paclitaxel (Pac). A layer-by-layer depth-scan SERS analysis of Dox and Pac treated spheroids reveals the spectral changes at around 555 cm-1 and 675 cm-1 originating from cholesterol and guanine, respectively, compared to control (un-treated) spheroids. Higher spectral variation is observed from the inner to the outer layers of spheroid surface. The results demonstrate that the approach can be used to monitor the intracellular responses, which are in correlation with endolysosomal pathway according to the depth-layers of intact and living 3D spheroids upon external stimuli. © 2018 Elsevier B.V Daha fazlası Daha az

Baysal, A. | Saatci, A.D. | Kahraman, M. | Akman, S.

Article | 2011 | Microchimica Acta173 ( 03.04.2020 ) , pp.495 - 502

We report on the separation and preconcentration of lead(II) and copper(II) ions using silver-coated titanium dioxide nanoparticles modified with cysteamine, and their determination by slurry analysis via flame atomic absorption spectrometry. The ions were adsorbed via a conventional batch technique, and the ion-loaded slurry was separated and directly introduced into the spectrometer, thereby eliminating a number of drawbacks. The effects of pH, amount of sorbent, slurry volume, sample volume and other ions on the recovery were investigated. Under optimized experimental conditions, copper and lead can be recovered within the 95% co . . .nfidence level in certificated waste water, but also in spiked sea water samples. The technique is fast, simple, and leads to complete elution. The limit of detection (3?, at n = 10) was 0. 37 µg L-1 for Cu(II), and 0. 38 µg L-1 for Pb(II). © 2011 Springer-Verlag Daha fazlası Daha az