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Coronary artery bypass surgery provokes alzheimer's disease-like changes in the cerebrospinal fluid

A. Palotás | H.J. Reis | G. Bogáts | B. Babik | M. Racsmány | L. Engvau | J. Kálmán

Article | 2010 | Journal of Alzheimer's Disease21 ( 4 ) , pp.1153 - 1164

Several biomarkers are used in confirming the diagnosis of cognitive disorders. This study evaluates whether the level of these markers after heart surgery correlates with the development of cognitive dysfunction, which is a frequent complication of cardiac interventions. Concentrations of amyloid-ß peptide, tau, and S100ß in the cerebro-spinal fluid were assessed, as well as cognitive functions were evaluated before and after coronary artery bypass grafting, utilizing immuno-assays and psychometric tests, respectively. A drastic rise in the level of S100ß was observed one week after the surgery, a mark of a severe generalized cereb . . .ral injury. The level of amyloid-ß peptide significantly decreased, whereas the concentration of tau markedly increased six months postoperatively. Gradual cognitive decline was also present. These findings clearly demonstrate post-surgical cognitive impairment associated with changes in biomarkers similar to that seen in Alzheimer's disease, suggesting a unifying pathognomic factor between the two disorders. A holistic approach to coronary heart disease and Alzheimer's-type dementia is proposed. © 2010 IOS Press and the authors. All rights reserved Daha fazlası Daha az


Demirci, E. | Toklu, T. | Yeyin, N. | Ocak, M. | Alan-Selcuk, N. | Araman, A. | Kabasakal, L.

Article | 2018 | Radiation Protection Dosimetry182 ( 4 ) , pp.518 - 524

68 Ga-PSMA-11 PET/CT has been proven to have high clinical value for imaging of prostate cancer and rapidly gained popularity. In this study, we aimed to investigate absorbed doses of 68 Ga-PSMA-11. Seven patients (mean age = 66.9 ± 6.6 years, range: 57-79 years) were enrolled in the study. Whole body PET images were acquired with multiple time points. MIRD method, NUKFIT and OLINDA/EXM software were used for dosimetry calculations. Kidneys, bladder wall, salivary and lacrimal glands received the highest absorbed dose. Estimated absorbed doses to these organs after injection of 150 MBq 68 Ga-PSMA-11 were 37.0, 12.6, 14.4 and 6.3 mSv . . ., respectively. Effective dose from PET scanning with 150 MBq injected 68 Ga-PSMA-11 was 2.5 mSv. In conclusion, 68 Ga-PSMA-11 has a favorable dosimetry profile similar to the 68 Ga labeled octreotide analogs, which are used safely in routine clinical practices for many years. No adverse effects were reported. The kidneys were the dose-limiting organs. © The Author(s) 2018. Published by Oxford University Press. All rights reserved Daha fazlası Daha az

In vitro effect of cavity disinfectants on the bond strength of dentin bonding systems

Say, E.C. | Koray, F. | Tarim, B. | Soyman, M. | Gülmez, T.

Article | 2004 | Quintessence International35 ( 1 ) , pp.56 - 60

Objective: To evaluate the effect of two cavity disinfectants, a 2% chlorhexidine and a 1% benzalkonium chloride solution, on the shear and tensile bond strengths of dentin bonding systems to dentin. Method and materials: Superficial dentin was exposed from 84 freshly extracted human third molars. The teeth were randomly assigned to two main groups according to the bonding agent used, either One Step or Optibond Solo. Each dentin bonding system had six test groups (three for shear, three for tensile testing), and each test group had a control and two cavity disinfectant groups. In the control groups, dentin bonding systems were appl . . .ied after etching the dentin, whereas in the cavity disinfectant groups, dentin was conditioned and treated for 20 seconds with the disinfectants before applying the dentin bonding systems. A hybrid resin composite then was applied to all treated samples. After storage in distilled water at 37°C for 24 hours, shear and tensile tests were performed. Data were analyzed using Kruskall-Wallis and Mann-Whitney U tests. Results: The mean shear and tensile bond strengths of One Step and Optibond Solo were not significantly different from each other, and the cavity disinfectants also had no significant effects on shear and tensile bond strength values versus the controls. Conclusion: The results indicate that the use of 2% chlorhexidine and 1% benzalkonium chloride solutions as cavity disinfectants after etching the dentin did not affect the shear and tensile bond strengths of One Step and Optibond Solo Daha fazlası Daha az

Effect of ligand binding on the intraminimum dynamics of proteins

Alakent, B. | Baskan, S. | Doruker, P.

Article | 2011 | Journal of Computational Chemistry32 ( 3 ) , pp.483 - 496

Effects of ligand binding on protein dynamics are studied via molecular dynamics (MD) simulations on two different enzymes, dihydrofolate reductase (DHFR) and triosephosphate isomerase (TIM), in their unliganded (free) and liganded states. Domain motions in MD trajectories are analyzed by collectivities and rotation angles along the principal components (PCs). DHFR in the free state has well-defined domain rotations, whereas rotations are slightly damped in the binary complex with nicotinamide adenine dinucleotide phosphate (NADPH), and remarkably distorted in the presence of NADP+, showing that NADP+ is solely responsible for the l . . .oss of correlation of the domains in DHFR. Although mean square fluctuations of MD simulations in the same PC subspaces are similar for different ligation states, linear stochastic time series models show that backbone flexibility along the first five PCs is decreased upon NADPH and NADP+ binding in subpicosecond scale. This shows that mobility of the protein along the PCs is closely related with intraminimum dynamics, and alterations in ligation states may change the intraminimum dynamics significantly. Low vibrational frequencies of the alpha-carbon atoms of DHFR are determined from the time series models of a larger number of low indexed PCs, and it is found that number of modes in the lowest frequencies is reduced upon ligand binding. A similar result is obtained for TIM in the unliganded and dihydroxyacetone phosphate bound states. We suggest that stochastic time series modeling is a promising method to be used in determining subtle perturbations in protein dynamics. © 2010 Wiley Periodicals, Inc Daha fazlası Daha az

Surface-enhanced Raman spectroscopy based 3D spheroid culture for drug discovery studies

Altunbek, M. | Çetin, D. | Suludere, Z. | Çulha, Mustafa

Article | 2019 | Talanta191 , pp.390 - 399

Three-dimensional (3D) spheroid cultures are more realistic tissue mimicking structures for drug discovery studies. However, analysis of 3D spheroid cultures is a challenge task because available techniques are destructive, which results with the loss of biochemical information confined in a spatial arrangement inside of spheroids. In this study, a surface-enhanced Raman scattering (SERS) based non-destructive approach is reported to study 3D cultures. Since the technique uses gold nanoparticles (AuNPs) as SERS substrates, the cells treated with AuNPs are used for the preparation of spheroids. Since SERS spectra originate from molec . . .ular species near AuNPs and their aggregates in endolysosomes, the obtained spectral information can provide significant level of information about biomolecular processes taking place in endolysosomes and dependently in cells. The performance of the approach is evaluated by monitoring the spectral changes upon external stimuli with Doxorubicin (Dox) and Paclitaxel (Pac). A layer-by-layer depth-scan SERS analysis of Dox and Pac treated spheroids reveals the spectral changes at around 555 cm-1 and 675 cm-1 originating from cholesterol and guanine, respectively, compared to control (un-treated) spheroids. Higher spectral variation is observed from the inner to the outer layers of spheroid surface. The results demonstrate that the approach can be used to monitor the intracellular responses, which are in correlation with endolysosomal pathway according to the depth-layers of intact and living 3D spheroids upon external stimuli. © 2018 Elsevier B.V Daha fazlası Daha az

Translucency of ceramic material in different core-veneer combinations

Kursoglu, P. | Karagoz Motro, P.F. | Kazazoglu, E.

Article | 2015 | Journal of Prosthetic Dentistry113 ( 1 ) , pp.48 - 53

Statement of problem Understanding the translucency of ceramic materials is important to achieve good esthetics. Ceramic thickness is related to translucency; however, less information about core-veneer thickness in combination is available. Purpose The purpose of this study was to investigate the translucency parameters of core-veneer thicknesses in 2 different ceramic materials. Material and Methods A total of 56 ceramic disks of different thickness were fabricated as cores according to the manufacturer's recommendations and divided into groups (n=7). Each was veneered with its compatible veneer ceramic with a different thickness . . .(0.2, 0.5, 0.7 mm). One group of each ceramic type was left without veneer. The groups were named according to core names (group IPS e.max Press [EP], group IPS Empress Esthetic [EE]), and numbers were given according to thickness combination: 1=(1.00+0.5); 2=(0.8+0.7); 3=(1.00); 4=(0.8+0.2). All surfaces were measured by profilometry to ensure consistency within the groups. A glass disk (1.5 mm) positive control (group P) and a metal core (1.5 mm) negative control (group N) were prepared. The translucency parameter values were calculated by using spectrophotometry to calculate the color differences of the specimens over black and white backgrounds. Results A 1-way ANOVA found significant differences among the translucency parameter values of the ceramic groups (P.05). Conclusions Total ceramic thickness affected the translucency; higher combined ceramic thickness resulted in lower translucency parameter values. When total thickness decreases, the translucency of core material has more effect than that of veneer material on translucency parameter values. © 2015 Editorial Council for the Journal of Prosthetic Dentistry Daha fazlası Daha az

Systematic review of prosthetic maintenance requirements for implant-supported overdentures

Çehreli, M.C. | Karasoy, D. | Kökat, A.M. | Akça, K. | Eckert, S.E.

Article | 2010 | International Journal of Oral and Maxillofacial Implants25 ( 1 ) , pp.163 - 180

Orthodontic treatment of a transmigrated mandibular canine: a case report.

Trakyali, G. | Cildir, S.K. | Sandalli, N.

Article | 2010 | Australian orthodontic journal26 ( 2 ) , pp.195 - 200

Intraosseous migration of a lower canine across the midline is a rare dental anomaly. The treatment options include: forced eruption of the unerupted tooth using orthodontic traction, autotransplantation, extraction followed by prosthetic replacement. To report the management of a transmigrated lower right canine. The treatment involved surgical, orthodontic and cosmetic dental treatment. No permanent teeth were extracted. The transmigrated canine was placed between the left central and lateral incisors and the crown recontoured to simulate a lateral incisor. An acceptable aesthetic and functional outcome was gained. Transmigration . . .is a rare dental condition that can be treated successfully with a collaborative effort from several dental disciplines Daha fazlası Daha az

Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis

Tzu, J.H. | Utine, C.A. | Stern, M.E. | Akpek, E.K.

Article | 2012 | Cornea31 ( 6 ) , pp.649 - 654

Purpose: To evaluate the long-term effectiveness of the combination of topical cyclosporine drops and tacrolimus ointment in the treatment of steroid-dependent atopic keratoconjunctivitis (AKC). Methods: Ten patients with moderate to severe AKC participated in the study. Topical cyclosporine 0.05% was used, as a monotherapy, 6 times daily during the first month of the study, followed by 4 times daily during the second month. The patients were then instructed to self-treat with topical cyclosporine at a dose ranging from 2 to 6 times daily depending on the severity of the disease. Tacrolimus ointment 0.03% was applied on the lid skin . . .. Follow-up examinations were performed approximately every 3 months. Each patient completed a follow-up period of at least 12 months. Symptoms and signs of AKC were assessed on the day of enrollment, on days 28, 56, and 63, and at subsequent follow-up visits. Flare-ups of AKC requiring steroid use and progression of the disease findings were also recorded. Results: All patients experienced significant improvement of their symptoms and signs during the first 2 months of the study. Two patients were lost to follow-up after the initial 2 months. One patient was noncompliant and continued the treatment only for 7 months. During the median treatment period of 21.5 months for the 7 continuing patients, a total of only 2 flare-up episodes were noted requiring topical steroids. Conclusions: Adequate topical immunomodulation using topical calcineurin inhibitors may eliminate the need for steroids and favorably alter the long-term prognosis of patients with AKC. Copyright © 2012 by Lippincott Williams & Wilkins Daha fazlası Daha az

Intrusion of an overerupted mandibular molar using mini-screws and mini-implants: A case report

Arslan, A. | Ozdemir, D.N. | Gursoy-Mert, H. | Malkondu, O. | Sencift, K.

Article | 2010 | Australian Dental Journal55 ( 4 ) , pp.457 - 461

Overeruption of mandibular molars due to the loss of antagonist teeth causes occlusal functional disturbances. To restore proper occlusion, intrusion of the overerupted molars becomes essential before multidisciplinary reconstructive dental approaches can be initiated. Treatment protocols involving prosthodontic reduction, surgical impaction, and conventional orthodontic intrusion have been introduced. Orthodontic intrusion seems to be a favourable procedure which requires calibrated anchorage support. This case illustrates the management of a complex dental and functional problem with an interdisciplinary approach through the use o . . .f orthodontic, periodontal, restorative and implant therapy. In order to intrude the overerupted molar, a partial orthodontic appliance was used in conjunction with mini-implants and mini-screws. The results showed that the biological responses of the teeth and the surrounding bony structures to the intrusion appeared normal and acceptable. Periodontal health and vitality of the teeth were maintained throughout the treatment and even after one-year follow-up. © 2010 Australian Dental Association Daha fazlası Daha az

Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: A 1-year follow-up study

Tekce, M. | Ince, G. | Gursoy, H. | Dirikan Ipci, S. | Cakar, G. | Kadir, T. | Yilmaz, S.

Article | 2015 | Journal of Clinical Periodontology42 ( 4 ) , pp.363 - 372

Aim The objective of this study was to evaluate the effects of lozenges containing L. reuteri as an adjuvant treatment to initial periodontal therapy for chronic periodontitis patients and to detect the level of L. reuteri colonization in the periodontal pockets of treated patients. Material and Methods A total of 40 patients were selected and randomly divided into two groups. Each patient had at least two teeth with one approximal site each with a probing depth (PD) of 5-7 mm and gingival index (GI) of ?2 in each quadrant. Group I received scaling and root planing (SRP) plus L. reuteri-containing lozenges, and Group II received SRP . . . plus placebo. The plaque index (PI), GI, bleeding on probing (BoP), PD and relative attachment level were measured. Microbiological sampling was performed at baseline and on days 21, 90, 180 and 360 and were analysed by culturing. The Bonferroni-corrected paired sample t-test, Bonferroni-corrected Wilcoxon signed rank test and paired sample t-test were used to evaluate intra-group differences. The Bonferroni-corrected Student's t-test and the Mann-Whitney U-tests were used to evaluate inter-group differences. Results After treatment, the measured PI, GI, BoP and PD were significantly (p < 0.05) lower in Group I compared with Group II at all time points. Similar observations were made for the total viable cell counts and the proportions of obligate anaerobes with the exception of day 360. In Group I, significantly fewer patients required surgery on ?3 sites. Conclusion L. reuteri-containing lozenges may be a useful adjuvant agent to slow re-colonization and improve clinical outcomes of chronic periodontitis. Further studies are required to clarify the optimal dose of the lozenges. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Daha fazlası Daha az

Agmatine Reverses Sub-chronic Stress induced Nod-like Receptor Protein 3 (NLRP3) Activation and Cytokine Response in Rats

Sahin, C. | Albayrak, O. | Akdeniz, T.F. | Akbulut, Z. | Yanikkaya Demirel, G. | Aricioglu, F.

Article | 2016 | Basic and Clinical Pharmacology and Toxicology119 ( 4 ) , pp.367 - 375

The activation of Nod-like receptor protein 3 (NLRP3) has lately been implicated in stress and depression as an initiator mechanism required for the production of interleukin (IL)-1ß and IL-18. Agmatine, an endogenous polyamine widely distributed in mammalian brain, is a novel neurotransmitter/neuromodulator, with antistress, anxiolytic and antidepressant-like effects. In this study, we examined the effect of exogenously administered agmatine on NLRP3 inflammasome pathway/cytokine responses in rats exposed to restraint stress for 7 days. The rats were divided into three groups: stress, stress+agmatine (40 mg/kg; i.p.) and control gr . . .oups. Agmatine significantly down-regulated the gene expressions of all stress-induced NLRP3 inflammasome components (NLRP3, NF-?B, PYCARD, caspase-1, IL-1ß and IL-18) in the hippocampus and prefrontal cortex (PFC) and reduced pro-inflammatory cytokine levels not only in both brain regions, but also in serum. Stress-reduced levels of IL-4 and IL-10, two major anti-inflammatory cytokines, were restored back to normal by agmatine treatment in the PFC. The findings of the present study suggest that stress-activated NLRP3 inflammasome and cytokine responses are reversed by an acute administration of agmatine. Whether antidepressant-like effect of agmatine can somehow, at least partially, be mediated by the inhibition of NLRP3 inflammasome cascade and relevant inflammatory responses requires further studies in animal models of depression. © 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society Daha fazlası Daha az

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