Modeling 3D melt electrospinning writing by response surface methodology

Dayan, C.B. | Afghah, F. | Okan, B.S. | Yıldız, M. | Menceloglu, Y. | Çulha, Mustafa | Koc, B.

Article | 2018 | Materials and Design148 , pp.87 - 95

Three-dimensional (3D) melt electrospinning writing (MEW) is a promising technique for 3D printing of porous scaffolds with well-defined geometrical features. The diameter of electrospun fibers strongly affect the achievable resolution and consequently several other physical, mechanical, and structural properties of the fabricated scaffold. However, there are a few process parameters which significantly affect the size of electrospun fibers. In this study, response surface methodology (RSM) was used to investigate the critical and optimized process parameters and their interaction effects on the desired fiber diameter. Four process . . .parameters, including collector speed, tip-to-collector distance, applied pressure, and voltage were studied considering their practical ranges. The results showed that all the parameters except the applied voltage had a significant effect on the printed fiber diameters. A generalized model for the interaction effects of the parameters was introduced which can be used as a framework for selecting the process parameters to achieve the desired fiber diameter. The developed model was validated by choosing random process parameters and printing three-dimensional scaffolds. The results confirm that the predicted fiber diameters match closely with the actual fiber diameters measured directly from the printed scaffold. © 2018 Elsevier Lt Daha fazlası Daha az

Hierarchically porous polymer derived ceramics: A promising platform for multidrug delivery systems

Vakifahmetoglu, C. | Zeydanli, D. | Ozalp, V.C. | Borsa, B.A. | Soraru, G.D.

Article | 2018 | Materials and Design140 , pp.37 - 44

Mesoporous silicon oxycarbide (SiOC) components were formed with the use of “molecular spacer” (a sacrificial vinyl-terminated linear siloxane which while decomposing during pyrolysis generates pores with size proportional to the molecular weight), followed by a post-pyrolysis etching treatment by hydrofluoric acid (HF) to obtain C-rich SiOC samples having additional micro-/mesoporosity and specific surface area reaching to 774 m2/g. The biocompatibility of the samples was validated by hemolysis test, and their cargo/drug loading capacities were studied by two different sized polypeptides as model molecules. SiOC particles showed le . . .ss hemolysis compared to the reference material MCM-41. Similarly, the loading capacity and the release kinetics of bovine serum albumin (BSA) and vancomycin-loaded SiOC particles were improved compared to that of MCM-41. In the multi cargo loading/release capacity tests, done by using different sized molecules, Bio2-HF and MCM-41 were loaded both with fluorescein and BSA. While a lagging time in fluorescein release was observed for MCM-41, the release kinetics of fluorescein and BSA was not affected when they are loaded together in the hierarchical pores of Bio2-HF, allowing the release of both large and small cargo molecules. The antimicrobial activity tests showed that Bio2-HF performed better than MCM-41 particles in improving bactericidal activity. © 2017 Elsevier Lt Daha fazlası Daha az

Corrigendum to “Hierarchically porous polymer derived ceramics: A promising platform for multidrug delivery systems” (Mater. Des. (2018) (140) (Supplement C) (37–44)(S026412751731078X)(10.1016/j.matdes.2017.11.047))

Vakifahmetoglu, C. | Zeydanli, D. | Ozalp, V.C. | Borsa, B.A. | Soraru, G.D.

Erratum | 2018 | Materials and Design142 , pp.37 - 44

The authors regret to inform that The TMTVS ratios for samples were written incorrectly. The true weight ratios for PHMS/LDH/PDMS/TMTVS blends should be as follows: Bio1 = 1/0.055/0.25/0.055, and Bio2 = 1/0.055/1/0.055. The discussion in the study is not affected by this mistype and actually the previous paper [1] cited also in the paper as ref.#44 gives right values for the sample preparation. The authors would like to apologize for the inconvenience caused. © 2018 Elsevier Ltd

6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.