Association of monocyte chemotactic protein-1 and CC chemokine receptor 2 gene variants with preeclampsia
Preeclampsia complicates 10% of pregnancies in developing countries. It is one of the leading causes of maternal and fetal/neonatal mortality and morbidity worldwide. It has been suggested that maladaptation of the maternal immune response during pregnancy might be a causal factor for preeclampsia. According to immune maladaptation hypothesis, preeclampsia is due to an inappropriate regulation of normally Th2-deviated maternal immune responses, leading to a shift toward harmful Th1 immunity. Several studies indicate that monocyte chemotactic protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) are involved in Th1 and Th2 immunity. In this study, we investigated the association between MCP-1 A-2518G and CCR2-V64I polymorphisms and preeclampsia. One hundred eighty preeclamptic pregnant women and 145 healthy controls were included in the study. We observed that in preeclamptic women, MCP-1 G: CCR2 Val haplotype was significantly higher when compared with other haplotypes. In conclusion, we stated that MCP-1 and CCR2 gene variants might be associated with preeclampsia. © Mary Ann Liebert, Inc.
| Yazar |
Agachan, B. Attar, Rukset Isbilen, E. Aydogan, H.Y. Sozen, S. Gurdol, F. İşbir, Turgay |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.11831/5685 |
| Koleksiyonlar |
Araştırma Çıktıları | Ön Baskı | WoS | Scopus | TR-Dizin | PubMed 02- WoS İndeksli Yayınlar Koleksiyonu 03- Scopus İndeksli Yayınlar Koleksiyonu 05- PubMed İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | Journal of Interferon and Cytokine Research |
| Cild | 30 |
| Dergi Sayısı | 9 |
| Sayfalar | 673 - 676 |
| Yayın Tarihi | 2010 |
| Eser Adı [dc.title] | Association of monocyte chemotactic protein-1 and CC chemokine receptor 2 gene variants with preeclampsia |
| Yazar [dc.contributor.author] | Agachan, B. |
| Yazar [dc.contributor.author] | Attar, Rukset |
| Yazar [dc.contributor.author] | Isbilen, E. |
| Yazar [dc.contributor.author] | Aydogan, H.Y. |
| Yazar [dc.contributor.author] | Sozen, S. |
| Yazar [dc.contributor.author] | Gurdol, F. |
| Yazar [dc.contributor.author] | İşbir, Turgay |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | Preeclampsia complicates 10% of pregnancies in developing countries. It is one of the leading causes of maternal and fetal/neonatal mortality and morbidity worldwide. It has been suggested that maladaptation of the maternal immune response during pregnancy might be a causal factor for preeclampsia. According to immune maladaptation hypothesis, preeclampsia is due to an inappropriate regulation of normally Th2-deviated maternal immune responses, leading to a shift toward harmful Th1 immunity. Several studies indicate that monocyte chemotactic protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) are involved in Th1 and Th2 immunity. In this study, we investigated the association between MCP-1 A-2518G and CCR2-V64I polymorphisms and preeclampsia. One hundred eighty preeclamptic pregnant women and 145 healthy controls were included in the study. We observed that in preeclamptic women, MCP-1 G: CCR2 Val haplotype was significantly higher when compared with other haplotypes. In conclusion, we stated that MCP-1 and CCR2 gene variants might be associated with preeclampsia. © Mary Ann Liebert, Inc. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2020-03-18 |
| Yayın Tarihi [dc.date.issued] | 2010 |
| Açık Erişim Tarihi [dc.date.available] | 2020-03-18 |
| Dil [dc.language.iso] | eng |
| Haklar [dc.rights] | info:eu-repo/semantics/closedAccess |
| ISSN [dc.identifier.issn] | 10799907 |
| Yayının ilk sayfa sayısı [dc.identifier.startpage] | 673 |
| Yayının son sayfa sayısı [dc.identifier.endpage] | 676 |
| Dergi Adı [dc.relation.journal] | Journal of Interferon and Cytokine Research |
| Dergi Sayısı [dc.identifier.issue] | 9 |
| Cild [dc.identifier.volume] | 30 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.11831/5685 |
| Pubmed Id [dc.identifier.pubmed] | PubMed ID: 20726788 |
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