The role of TWIST, SERPINB5, and SERPIN1 genes in uterine leiomyomas
Objective: The aim of this study is investigate the role of the Twist homolog 1 (TWIST), serine peptidase inhibitor (SERPINB5), and plasminogen activator inhibitor 1 (SERPIN1) genes in uterine leiomyoma etiopathogenesis. Material and Methods: Twelve patients, aged between 39 and 58, and had a hysterectomy, were included in the study. The size of the leio- myomas was between 20 and 130 mm based on gross pathology after hysterectomy. Tissue samples were obtained from normal myometrium and leiomyoma (1 cm3) tissue of the uterus of the patients and stored at -86°C. Samples were divided to two groups after histopathological evaluation of the uterus: normal myometrial tissues as control group (Group 1) and leiomyoma tissue as the study group (Group 2). The TWIST, SERPINB5, and SERPIN1 genes were studied for uterine leiomyoma etiopathogenesis. Results: TWIST gene expression was significantly higher in the uterine leiomyoma tissue (p<0.001). SERPINB5 and SERPIN1 gene expression was decreased in the uterine leiomyoma tissue, but the differences were not statistically significant. Conclusion: TWIST gene activity is significantly increased in leiomyoma tissue when compared to normal myometrium. In spite of the fact that the development of uterine leiomyomas is estrogen- and progesterone-dependent, myometrial cells could be triggered by the TWIST gene for uterine leiomyoma development. (J Turk Ger Gynecol Assoc 2014; 15: 92-5)
| Yazar |
Bostancı, Mehmet Süha Bayram, Merih Celtemen, Baran Bakacak, Süleyman Murat Kızılkale, Özge Yıldırım Attar, Rukset Ümit, Emin Bağrıaçık |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.11831/4190 |
| Konu Başlıkları | Kadın Hastalıkları ve Doğum |
| Koleksiyonlar |
Araştırma Çıktıları | Ön Baskı | WoS | Scopus | TR-Dizin | PubMed 03- Scopus İndeksli Yayınlar Koleksiyonu 04- TR-Dizin İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | Journal of the Turkish-German Gynecological Association |
| Cild | 15 |
| Dergi Sayısı | 2 |
| Sayfalar | 92 - 95 |
| Yayın Tarihi | 2014 |
| Eser Adı [dc.title] | The role of TWIST, SERPINB5, and SERPIN1 genes in uterine leiomyomas |
| Yazar [dc.contributor.author] | Bostancı, Mehmet Süha |
| Yazar [dc.contributor.author] | Bayram, Merih |
| Yazar [dc.contributor.author] | Celtemen, Baran |
| Yazar [dc.contributor.author] | Bakacak, Süleyman Murat |
| Yazar [dc.contributor.author] | Kızılkale, Özge Yıldırım |
| Yazar [dc.contributor.author] | Attar, Rukset |
| Yazar [dc.contributor.author] | Ümit, Emin Bağrıaçık |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | Objective: The aim of this study is investigate the role of the Twist homolog 1 (TWIST), serine peptidase inhibitor (SERPINB5), and plasminogen activator inhibitor 1 (SERPIN1) genes in uterine leiomyoma etiopathogenesis. Material and Methods: Twelve patients, aged between 39 and 58, and had a hysterectomy, were included in the study. The size of the leio- myomas was between 20 and 130 mm based on gross pathology after hysterectomy. Tissue samples were obtained from normal myometrium and leiomyoma (1 cm3) tissue of the uterus of the patients and stored at -86°C. Samples were divided to two groups after histopathological evaluation of the uterus: normal myometrial tissues as control group (Group 1) and leiomyoma tissue as the study group (Group 2). The TWIST, SERPINB5, and SERPIN1 genes were studied for uterine leiomyoma etiopathogenesis. Results: TWIST gene expression was significantly higher in the uterine leiomyoma tissue (p<0.001). SERPINB5 and SERPIN1 gene expression was decreased in the uterine leiomyoma tissue, but the differences were not statistically significant. Conclusion: TWIST gene activity is significantly increased in leiomyoma tissue when compared to normal myometrium. In spite of the fact that the development of uterine leiomyomas is estrogen- and progesterone-dependent, myometrial cells could be triggered by the TWIST gene for uterine leiomyoma development. (J Turk Ger Gynecol Assoc 2014; 15: 92-5) |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2020-03-18 |
| Yayın Tarihi [dc.date.issued] | 2014 |
| Açık Erişim Tarihi [dc.date.available] | 2020-03-18 |
| Dil [dc.language.iso] | eng |
| Konu Başlıkları [dc.subject] | Kadın Hastalıkları ve Doğum |
| Haklar [dc.rights] | info:eu-repo/semantics/openAccess |
| ISSN [dc.identifier.issn] | 1309-0399 |
| ISSN [dc.identifier.issn] | 1309-0380 |
| Yayının ilk sayfa sayısı [dc.identifier.startpage] | 92 |
| Yayının son sayfa sayısı [dc.identifier.endpage] | 95 |
| Dergi Adı [dc.relation.journal] | Journal of the Turkish-German Gynecological Association |
| Dergi Sayısı [dc.identifier.issue] | 2 |
| Cild [dc.identifier.volume] | 15 |
| Tek Biçim Adres [dc.identifier.uri] | http://www.trdizin.gov.tr/publication/paper/detail/TVRVNU1UQXhNUT09 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.11831/4190 |
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