Personalized Evaluation of Oxygen and Carbon Dioxide Exchange in COVID-19 Patients with Regard to Energy Homeostasis

The COVID-19 does not proceed the same way in every patient. It may interfere with both oxygen (O2) and carbon dioxide (CO2) exchange in the alveoli; therefore, prevent ATP generation; subsequently, restrict energy supply for the life processes of the patient. Data sets representing the course of the COVID-19 in four patients, where the disease followed dissimilar paths were reassessed after the end of the treatment, by focusing on the respiratory and metabolic energy related parameters (FiO2, PaO2, SaO2, PaCO2) and the other parameters such as HCO3, lactate, body temperature, C-reactive protein (CRP) and blood urea nitrogen levels. The valuable treatment data pertinent to each individual showed that each of them needed a personal treatment method. Group based statistical analyses may cause loss of the valuable medical information, if some of the dissimilar treatment details is considered as outliers. NIH has very recently reported that, there is no sufficient data yet to recommend either for or against the use of extracorporeal membrane oxygenation (ECMO) in the treatment of the COVID-19 patients. However, the results of this study suggest that ECMO may be useful for removal of the CO2 from some of the COVID-19 patients; therefore, will be helpful if used in their treatment.

Yazar Yılmaz, Bayram
Temur, Sibel
Ercan, Sina
Akduman, Seha
Gücü, Ecem
Erdoğan, Cihan Süleyman
Yenikale, Ayberk
Özilgen, Mustafa
Yayın Türü Preprint
Tek Biçim Adres https://hdl.handle.net/20.500.11831/7958
Konu Başlıkları COVID-19
ECMO
Energy metabolism
Extracorporeal methods
Oxygen and carbon dioxide exchange
Pneumonia
Koleksiyonlar Ön Baskı Yayınlar
Sayfalar -
Yayın Tarihi 2021
Yazar
[dc.contributor.author]
Yılmaz, Bayram
Yazar
[dc.contributor.author]
Temur, Sibel
Yazar
[dc.contributor.author]
Ercan, Sina
Yazar
[dc.contributor.author]
Akduman, Seha
Yazar
[dc.contributor.author]
Gücü, Ecem
Yazar
[dc.contributor.author]
Erdoğan, Cihan Süleyman
Yazar
[dc.contributor.author]
Yenikale, Ayberk
Yazar
[dc.contributor.author]
Özilgen, Mustafa
Eser Adı
[dc.title]
Personalized Evaluation of Oxygen and Carbon Dioxide Exchange in COVID-19 Patients with Regard to Energy Homeostasis
Yayın Türü
[dc.type]
preprint
Konu Başlıkları
[dc.subject]
COVID-19
Konu Başlıkları
[dc.subject]
ECMO
Konu Başlıkları
[dc.subject]
Energy metabolism
Konu Başlıkları
[dc.subject]
Extracorporeal methods
Konu Başlıkları
[dc.subject]
Oxygen and carbon dioxide exchange
Konu Başlıkları
[dc.subject]
Pneumonia
Yayın Tarihi
[dc.date.issued]
2021
Yayıncı
[dc.publisher]
Yeditepe University Academic and Open Access Information System
Dil
[dc.language.iso]
eng
Yayıncı Kategorisi
[dc.relation.publicationcategory]
Diğer
dc.contributor.institutionauthor
[dc.contributor.institutionauthor]
Bayram, Yılmaz
dc.contributor.institutionauthor
[dc.contributor.institutionauthor]
Temur, Sibel
dc.contributor.institutionauthor
[dc.contributor.institutionauthor]
Ercan, Sina
dc.contributor.institutionauthor
[dc.contributor.institutionauthor]
Akduman, Seha
dc.contributor.institutionauthor
[dc.contributor.institutionauthor]
Gücü, Ecem
dc.contributor.institutionauthor
[dc.contributor.institutionauthor]
Erdoğan, Cihan Süleyman
dc.contributor.institutionauthor
[dc.contributor.institutionauthor]
Yenikale, Ayberk
dc.contributor.institutionauthor
[dc.contributor.institutionauthor]
Özilgen, Mustafa
Diğer Yazarlar
[dc.contributor.authors]
Sina Ercan
Kayıt Giriş Tarihi
[dc.date.accessioned]
2021-09-04
Açık Erişim Tarihi
[dc.date.available]
2021-09-04
Özet
[dc.description.abstract]
The COVID-19 does not proceed the same way in every patient. It may interfere with both oxygen (O2) and carbon dioxide (CO2) exchange in the alveoli; therefore, prevent ATP generation; subsequently, restrict energy supply for the life processes of the patient. Data sets representing the course of the COVID-19 in four patients, where the disease followed dissimilar paths were reassessed after the end of the treatment, by focusing on the respiratory and metabolic energy related parameters (FiO2, PaO2, SaO2, PaCO2) and the other parameters such as HCO3, lactate, body temperature, C-reactive protein (CRP) and blood urea nitrogen levels. The valuable treatment data pertinent to each individual showed that each of them needed a personal treatment method. Group based statistical analyses may cause loss of the valuable medical information, if some of the dissimilar treatment details is considered as outliers. NIH has very recently reported that, there is no sufficient data yet to recommend either for or against the use of extracorporeal membrane oxygenation (ECMO) in the treatment of the COVID-19 patients. However, the results of this study suggest that ECMO may be useful for removal of the CO2 from some of the COVID-19 patients; therefore, will be helpful if used in their treatment.
Açıklama
[dc.description]
Note: This preprint reports new research that has not been certified by peer review and should not be used as established information without consulting multiple experts in the field
Haklar
[dc.rights]
Yeditepe University Academic and Open Access Information System
Yazar Departmanı
[dc.contributor.department]
Yeditepe University Faculty of Medicine
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.11831/7958
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22
20.03.2023 tarihinden bu yana
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20.03.2023 tarihinden bu yana
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02 Aralık 2023 08:23
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treatment COVID-19 patients valuable dissimilar therefore parameters energy patient method information medical analyses statistical oxygenation removal needed helpful showed individual pertinent personal details useful membrane extracorporeal against However either results recommend sufficient (ECMO) reported recently
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