Personalized evaluation of oxygen and carbon dioxide exchange in Covid-19 patients with regard to energy homeostasis

The COVID-19 does not proceed the same way in every patient. It may interfere with both oxygen (O2) and carbon dioxide (CO2) exchange in the alveoli; therefore, prevent ATP generation; subsequently, restrict energy supply for the life processes of the patient. Data sets representing the course of the COVID-19 in four patients, where the disease followed dissimilar paths were reassessed after the end of the treatment, by focusing on the respiratory and metabolic energy related parameters (FiO2, PaO2, SaO2, PaCO2) and the other parameters such as HCO3, lactate, body temperature, C-reactive protein (CRP) and blood urea nitrogen levels. The valuable treatment data pertinent to each individual showed that each of them needed a personal treatment method. Group based statistical analyses may cause loss of the valuable medical information, if some of the dissimilar treatment details is considered as outliers. NIH has very recently reported that, there is no sufficient data yet to recommend either for or against the use of extracorporeal membrane oxygenation (ECMO) in the treatment of the COVID-19 patients. However, the results of this study suggest that ECMO may be useful for removal of the CO2 from some of the COVID-19 patients; therefore, will be helpful if used in their treatment.

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Eser Adı
(dc.title)
Personalized evaluation of oxygen and carbon dioxide exchange in Covid-19 patients with regard to energy homeostasis
Yazar [Asıl]
(dc.creator.author)
Yılmaz, Bayram
Yazar Departmanı
(dc.creator.department)
Yeditepe Üniversitesi Tıp Fakültesi Fizyoloji Bölümü
Yazar Orcid
(dc.creator.orcid)
0000-0002-2674-6535
Yayın Tarihi
(dc.date.issued)
2021
Yayın Turu [Akademik]
(dc.type)
preprint
Yayın Türü [Ortam]
(dc.format)
application/pdf
Konu Başlıkları [Genel]
(dc.subject)
COVID-19
Konu Başlıkları [Genel]
(dc.subject)
ECMO
Konu Başlıkları [Genel]
(dc.subject)
Energy metabolism
Konu Başlıkları [Genel]
(dc.subject)
Extracorporeal methods
Konu Başlıkları [Genel]
(dc.subject)
Oxygen and carbon dioxide exchange
Konu Başlıkları [Genel]
(dc.subject)
Pneumonia
Yayıncı
(dc.publisher)
Yeditepe University Academic and Open Access Information System
Dil
(dc.language.iso)
eng
Özet Bilgisi
(dc.description.abstract)
The COVID-19 does not proceed the same way in every patient. It may interfere with both oxygen (O2) and carbon dioxide (CO2) exchange in the alveoli; therefore, prevent ATP generation; subsequently, restrict energy supply for the life processes of the patient. Data sets representing the course of the COVID-19 in four patients, where the disease followed dissimilar paths were reassessed after the end of the treatment, by focusing on the respiratory and metabolic energy related parameters (FiO2, PaO2, SaO2, PaCO2) and the other parameters such as HCO3, lactate, body temperature, C-reactive protein (CRP) and blood urea nitrogen levels. The valuable treatment data pertinent to each individual showed that each of them needed a personal treatment method. Group based statistical analyses may cause loss of the valuable medical information, if some of the dissimilar treatment details is considered as outliers. NIH has very recently reported that, there is no sufficient data yet to recommend either for or against the use of extracorporeal membrane oxygenation (ECMO) in the treatment of the COVID-19 patients. However, the results of this study suggest that ECMO may be useful for removal of the CO2 from some of the COVID-19 patients; therefore, will be helpful if used in their treatment.
Kayıt Giriş Tarihi
(dc.date.accessioned)
2021-09-04
Açık Erişim Tarihi
(dc.date.available)
2021-09-04
Haklar
(dc.rights)
Yeditepe University Academic and Open Access Information System
Erişim Hakkı
(dc.rights.access)
Open Access
Telif Hakkı
(dc.rights.holder)
Unless otherwise stated, copyrights belong to Yeditepe University. Usage permissions are specified in the Open Access System, and "InC-NC/1.0" and "by-nc-nd/4.0" are as stated.
Telif Hakkı Url
(dc.rights.uri)
http://creativecommons.org/licenses/by-nc-nd/4.0
Telif Hakkı Url
(dc.rights.uri)
https://rightsstatements.org/page/InC-NC/1.0/?language=en
Açıklama [Genel]
(dc.description)
Final published version
Açıklama [Not]
(dc.description.note)
Note: This preprint reports new research that has not been certified by peer review and should not be used as established information without consulting multiple experts in the field.
Tanım Koleksiyon Bilgisi
(dc.description.collectioninformation)
This item is part of the preprint collection made available through Yeditepe University library. For your questions, our contact address is openaccess@yeditepe.edu.tr
Yazar [KatkıdaBulunan]
(dc.contributor.author)
Temur, Sibel
Yazar [KatkıdaBulunan]
(dc.contributor.author)
Ercan, Sina
Yazar [KatkıdaBulunan]
(dc.contributor.author)
Akduman, Seha
Yazar [KatkıdaBulunan]
(dc.contributor.author)
Gücü, Ecem
Yazar [KatkıdaBulunan]
(dc.contributor.author)
Erdoğan, Cihan Süleyman
Yazar [KatkıdaBulunan]
(dc.contributor.author)
Yenikale, Ayberk
Yazar [KatkıdaBulunan]
(dc.contributor.author)
Özilgen, Mustafa
Yazar [KatkıdaBulunan] Kurum
(dc.contributor.institution)
Yeditepe University Faculty of Medicine
Tek Biçim Adres
(dc.identifier.uri)
https://hdl.handle.net/20.500.11831/7958
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