Personalized evaluation of oxygen and carbon dioxide exchange in Covid-19 patients with regard to energy homeostasis

Temur, Sibel | Ercan, Sina | Akduman, Seha | Gücü, Ecem | Erdoğan, Cihan Süleyman | Yenikale, Ayberk | Özilgen, Mustafa

Preprint | 2021 | Yeditepe University Academic and Open Access Information System

The COVID-19 does not proceed the same way in every patient. It may interfere with both oxygen (O2) and carbon dioxide (CO2) exchange in the alveoli; therefore, prevent ATP generation; subsequently, restrict energy supply for the life processes of the patient. Data sets representing the course of the COVID-19 in four patients, where the disease followed dissimilar paths were reassessed after the end of the treatment, by focusing on the respiratory and metabolic energy related parameters (FiO2, PaO2, SaO2, PaCO2) and the other parameters such as HCO3, lactate, body temperature, C-reactive protein (CRP) and blood urea nitrogen levels. . . . The valuable treatment data pertinent to each individual showed that each of them needed a personal treatment method. Group based statistical analyses may cause loss of the valuable medical information, if some of the dissimilar treatment details is considered as outliers. NIH has very recently reported that, there is no sufficient data yet to recommend either for or against the use of extracorporeal membrane oxygenation (ECMO) in the treatment of the COVID-19 patients. However, the results of this study suggest that ECMO may be useful for removal of the CO2 from some of the COVID-19 patients; therefore, will be helpful if used in their treatment Daha fazlası Daha az

Adrenergic modulation of melanocortin pathway by hunger signals

Temur, Sibel | Ercan, Sina | Akduman, Seha | Gücü, Ecem | Erdoğan, Cihan Süleyman | Yenikale, Ayberk | Özilgen, Mustafa

Article | 2023 | Nature CommunicationsVolume 14 ( Issue 1 )

Norepinephrine (NE) is a well-known appetite regulator, and the nor/adrenergic system is targeted by several anti-obesity drugs. To better understand the circuitry underlying adrenergic appetite control, here we investigated the paraventricular hypothalamic nucleus (PVN), a key brain region that integrates energy signals and receives dense nor/adrenergic input, using a mouse model. We found that PVN NE level increases with signals of energy deficit and decreases with food access. This pattern is recapitulated by the innervating catecholaminergic axon terminals originating from NTSTH-neurons. Optogenetic activation of rostral-NTSTH → . . . PVN projection elicited strong motivation to eat comparable to overnight fasting whereas its inhibition attenuated both fasting-induced & hypoglycemic feeding. We found that NTSTH-axons functionally targeted PVNMC4R-neurons by predominantly inhibiting them, in part, through α1-AR mediated potentiation of GABA release from ARCAgRP presynaptic terminals. Furthermore, glucoprivation suppressed PVNMC4R activity, which was required for hypoglycemic feeding response. These results define an ascending nor/adrenergic circuit, NTSTH → PVNMC4R, that conveys peripheral hunger signals to melanocortin pathway. © 2023, Springer Nature Limited Daha fazlası Daha az

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